Creamy Cajun Chicken Spaghetti Squash

Cajun Chicken Spaghetti Squash is made with Cajun-spiced chicken and roasted spaghetti squash tossed in a delicious cream sauce. This healthy low-carb recipe is packed with indulgent flavors that will have the whole family going back for more.

344 CALORIES23g CARBS10g FAT37g PROTEIN
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Cajun chicken and spaghetti squash? Seriously, I can’t think of a better duo. Whenever I go to an Italian restaurant, Cajun chicken pasta always seems to be the most tempting item on the menu. However, restaurant-style Cajun chicken pasta usually contains well over 1,500 calories and is loaded with sodium.

For the sake of my own peace of mind and not falling into a food coma after finishing my bowl, I decided to make my own lightened-up version of this iconic dish. Enter: Cajun Chicken Spaghetti Squash. This recipe is way lower in calories and carbs than the original, but with all the same decadent flavors you love.

This dish is made with pan-seared chicken breast, a cream cheese-based cream sauce, and veggies, served over delicious roasted spaghetti squash. Cajun Chicken Spaghetti Squash is an easy one-pan dinner recipe that comes together in just 30 minutes. It’s packed with essential nutrients and bursting with flavor.

I typically prepare my spaghetti squash ahead of time so it’s already roasted and ready to go. Then, all you have to do is saute your chicken and veggies, add your cream sauce ingredients, and mix it all together. Just like that, you’ve got a wholesome and delicious meal.

Try pairing this dish with a side salad like this Easy Spring Mix Salad or this Arugula Salad. You can also never go wrong with some toasted garlic bread on the side to soak up all of that creamy deliciousness. I’m telling you, you are about to fall in love with this recipe!

How to Pick Spaghetti Squash

Not sure how to choose the right spaghetti squash? Don’t worry. Below are some things to look out for when shopping for the perfect spaghetti squash.

  • Firmness: A good spaghetti squash should be firm enough that it doesn’t give when you press on it.
  • Skin: Its skin should be spotless and free of cracks and soft spots.
  • Stems: Try to avoid any spaghetti squashes that are missing their stems. Instead, look for stems that are firm, dry, and rounded.
  • Weight: The right spaghetti squash should feel a bit heavy for its size. Don’t be afraid to pick up a few different squashes to form a good comparison.

What You’ll Need for Cajun Spaghetti Squash

To make this healthy spaghetti squash recipe, you will need the following key ingredients:

  • Spaghetti Squash: Spaghetti squash is the perfect low-carb alternative to your favorite pasta noodles. It has a very mild flavor that pairs wonderfully with all sorts of sauces and toppings. For another low-carb alternative, you could try serving this dish with zucchini noodles instead.
  • Chicken breast: A good chicken pasta dish is hard to beat. Chicken breast is one of the leanest sources of animal-based protein and tastes incredible with Cajun seasoning.
  • Veggies: I like to use a combination of bell peppers, scallions, and onions for this recipe. They add tons of amazing color, flavor, and nutrients. Feel free to use any vegetables you have on hand. Broccoli and spinach both work great here.
  • Reduced-fat cream cheese: Herein lies the secret to this recipe’s delicious creaminess. Cream cheese serves as the base of our flavorful cream cheese and truly brings the whole dish together. To keep this dish on the lighter side, I like to use reduced-fat cream cheese.
  • Cajun seasoning: You can use the store-bought kind or make Cajun seasoning from scratch with paprika, garlic powder, onion powder, oregano, cayenne pepper, thyme, salt, and pepper.

Recipe Tips and Variations

Here are some of my top tips and variations for this flavorful dish:

  • Substitute your pasta. If you aren’t a fan of spaghetti squash, feel free to swap it out for another vegetable-based pasta instead. Some of my favorites are zucchini noodles and sweet potato noodles. Regular pasta works just fine, too!
  • Make it vegetarian. This dish tastes just as delicious sans-meat. The chicken in this dish can easily be swapped out for tofu, or simply left out altogether. You can also make it totally vegan by swapping out the cream cheese for a plant-based cream cheese instead.
  • Switch up the veggies. You can customize this dish depending on the veggies you have at home. Some of my favorite alternatives include spinach, mushrooms, asparagus, zucchini, and broccoli.
  • Add parmesan cheese. Mixing some parmesan cheese into your cream sauce adds a little extra oomph that will surely leave your whole family drooling.
  • Give it a kick. If you love spicy food as much as I do, try adding crushed red pepper or a few dashes of your favorite hot sauce.

Leftover Spaghetti Squash Storage Tips

If you haven’t yet cut into your spaghetti squash, it can be stored at room temperature for up to 3 months. However, if you’re looking to store your leftovers, wait for the dish to cool and transfer it to an airtight container. Once properly contained, you can store your leftover spaghetti squash in one of two ways:

  • In the fridge for up to 3-5 days.
  • In the freezer for up to 2-3 months.

To reheat the dish, thaw it in the fridge overnight first. Once thawed, add the leftovers to a microwave-safe container and heat for 60-90 seconds, stirring halfway through. Alternatively, you can reheat leftovers on your stovetop by placing them in a saucepan and cooking on medium to low heat until warmed through.

Frequently Asked Questions

Here are the answers to some of the most frequently asked questions about this healthy spaghetti squash recipe:

You can cook spaghetti squash either in the microwave or in the oven. To microwave, pierce the squash with a fork and cook it whole for 10-12 minutes. To bake the squash in the oven, cut it in half and spray with cooking spray. Then, place on a lined baking sheet and bake for 45-60 minutes at 375°F (until fork-tender).

Yes! In fact, spaghetti squash is a bit of a superfood. It’s incredibly low in calories but packed with essential vitamins, minerals, and antioxidants. Spaghetti squash is also super high in fiber, meaning it keeps you feeling full for longer.

The Cajun seasoning in this dish gives it a bit of a kick, but the heat is somewhat tempered by the dairy in the cream cheese. To make your Cajun chicken spaghetti squash even spicier, you could try adding extra Cajun seasoning or red pepper flakes into the mix. You could also add a few shakes of hot sauce just before serving the dish.

The Recipe
Cajun chicken spaghetti squash with peppers, chicken breast, a creamy tomato sauce, and spaghetti squash.

Creamy Cajun Chicken Spaghetti Squash

PREP TIME: 5 Min
COOK TIME: 25 Min
TOTAL TIME: 30 Min
2 Comments
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Ingredients

USMETRICS
  • 1 spaghetti squash
  • 1.33 lbs. boneless skinless chicken breast, cut into chunks
  • 2 tbsp. Cajun seasoning, divided (or more)
  • 2 tsp. olive oil
  • 1 red pepper, sliced thin
  • 1 green pepper, sliced thin
  • 1/2 red onion, sliced thin
  • 2 cloves garlic, minced (or more)
  • 14 oz. fire roasted diced tomatoes (not drained)
  • 1/2 cup reduced fat cream cheese
  • 1/4 cup scallions

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Instructions

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1

Prepare the spaghetti squash in the oven or microwave. To roast, preheat the oven to 375 degrees. Cut the squash in half and scoop out the seeds. Spray with cooking spray and place on a baking sheet covered in foil. Bake for 45-60 minutes until tender. To microwave pierce the squash all over with a knife or fork. Cook each squash whole for 10-12 minutes until tender. Carefully cut in half and remove seeds. Scrape the squash away from the skin using a fork.

2

Toss the chicken with half of the Cajun seasoning. Heat the olive oil over medium high heat in a skillet. Add the chicken and cook for 6-8 minutes, stirring often, until cooked through. Set aside.

3

Add the vegetables to the same pan and cook for 6-8 minutes until tender. If they begin to stick, add 1-2 tablespoons of water.

4

Turn heat down to low and add the diced tomatoes (undrained), cream cheese, and remaining Cajun seasoning. Cook until cream cheese melts and the sauce is formed. Taste and season if needed.

5

Stir in the chicken and spaghetti squash. Serve with scallions.

Nutritional Facts
Serving Size: 2 cups
Amount Per Serving
Calories 344
Calories from Fat 83
% Daily Value *
Total Fat 10g
14%
Saturated Fat 3g
16%
Monounsaturated Fat 0g
0%
Polyunsaturated Fat 0g
0%
Cholesterol 90mg
30%
Sodium 447mg
19%
Total Carbohydrate 23g
8%
Dietary Fiber 5g
22%
Sugars 11g
Protein 37g

* Percent Daily Values are based on a 2,000 calorie diet. Your daily values may be higher or lower depending on your calorie needs.

The Nutritional Values provided are estimates only and may vary based on the preparation method.

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About the authorMeet Kristen McCaffrey
Hi, I’m the cookbook author, recipe developer, and food enthusiast behind Slender Kitchen. I am obsessed with making healthy food that is easy to prepare and absolutely delicious. Meal planning is my secret weapon and I hope I can make meal time easier for you with our tried and tested recipes and foolproof meal plans. Learn More
2 Comments
On Creamy Cajun Chicken Spaghetti Squash
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Anna F
April 12, 2017 - 09:11
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5
This was delicious. I'm day dreaming about the leftovers I get to eat tonight!
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Marsha Russell
January 18, 2017 - 06:20
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5
I made this for supper last night, and my husband and I LOVED it!! The only tweaks I made were adding the whole 14 oz. can of fire roasted tomatoes since they are zero points on WW. This gave it a saucier consistency. Plus, instead of low fat cream cheese, I added 2 wedges of light Swiss Laughing Cow. Very flavorful recipe!!!
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