Grilled Mediterranean Pork Tenderloin

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Grilled Mediterranean Pork Tenderloin with a delicious homemade spice mix is tasty, easy to make, and a grilling favorite.

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Grilled Pork Tenderloin with a Mediterranean spice rub makes an easy and flavor packed dinner. Serve it with Grilled Red Potatoes or Grilled Mushrooms for a completely grilled meal.

Simple is sometimes the best idea when it comes to grilled meats in my opinion. Oftentimes when you go simple, whether with marinades or spice rubs, what happens is that the meat really gets to shine through and it creates the best flavors. 

I was thinking about this when I was staring at a pork tenderloin, trying to decide what flavor profile I wanted it to take on. I was starting to go off in a lot of different directions when I finally took a (figurative and literal) step back and decided to simplify, simplify, simplify.

After all, pork tenderloin on the grill is one of my favorite meats and I didn't want to ruin it by drowning it in flavors. Especially after all the trial and error it took for me to figure out how to cook it perfectly.

To that end, I created a simple, Mediterranean-inspired spice rub that contains oregano, thyme, paprika, and garlic to add a lot of flavor. The spice rub itself also works great on chicken breasts, chicken thighs, or fish. Grilled pork tenderloin with Mediterranean spices cut into slices with rosemary.

Ideas for Customizing Mediterranean Pork Tenderloin

If you're anything like me, then you may have found yourself also staring at a piece of meat wondering how to season it a time or two in your life. Maybe you're not feeling the Mediterranean spices. That's no problem!

There are so many ways to flavor pork tenderloin. That's why I love it so much. Its versatility allows me to keep creating new recipes over and over and never repeating them. Since we are sticking with simple here today though, what follows is, in no particular order, some of my favorite ways I've made pork tenderloin before.

  • Sweet and savory. When I made this Slow Cooker Maple Pork Tenderloin, I was in the mood for something both...sweet...and...savory. Maple is not the first thing you might think of when going sweet, but let me tell you the combo of maple with Dijon mustard on pork tenderloin is just divine. If you want to grill this, just marinade the tenderloin in the sauce overnight or for up to four hours before grilling.
  • Tex Mex. These South-of-the-Border-inspired Southwestern Grilled Pork Chops are made with spices you probably already have in your pantry and come together in a flash. You can use this spice rub on a tenderloin and grill it up according to the instructions below.
  • Asian-Inspired. Yumminess is an Asian pork recipe. This Grilled Asian Pork Tenderloin checks all my boxes: sweet, savory, spicy, simple, and oh-so-delicious!
  • Fruity. Yes, I said fruity! The addition of fruit salsa to pork is something you might not have considered but I promise, once you've tried it, you'll be hooked. A great gateway recipe to try this combo on is my Grilled Pork Chops with Peach Salsa.

Tips for Making This Mediterranean Pork Tenderloin

  • Be sure to rub a dry pork tenderloin. The spices will stick much better to a dry tenderloin than a wet one. Use paper towels to pat your meat dry before adding the rub.
  • Let the pork loin cook the full 7-8 minutes per side before flipping. If you keep checking for doneness or flip too soon, the meat will stick to the grill. It'll pull off easily when that side is done.
  • If your grill is in need of a cleaning and you are short on time, you can put down foil (there is a grilling foil as well with slats in it for meat juices to drip through), or consider oiling your grill grates (before lighting) to make sure your meat doesn't stick.
  • Add other spices or herbs to the dry rub if you like. Others that would work well include dried basil, cumin, rosemary, or parsley. To kick up the heat, add red pepper flakes, paprika, or chili powder.

Sliced grilled pork tenderloin with spice rub on a plate with a fork.

How Can I Use Leftover Mediterranean Pork Tenderloin?

I love making sandwiches with leftover pork. Cold or hot, they work so well! Add barbecue sauce, light mayo, slices of avocado, or a healthy slaw over the top and between your slices of bread.

Wraps and tacos work well too for thin-sliced leftover pork. Add your favorite ingredients and dive in. Or, if you are making a wrap, consider rolling it tight like a burrito and grilling it or pressing it on a grill pan on all sides for a nice, crunchy wrap.

Leftover meats also are great additional sources of protein for salads. Lay atop any salad you want to make or have on hand for a full meal. It's also delicious served on top of these Mediterranean Bowls.

The Recipe
Grilled Mediterranean Pork Tenderloin with a spice rub on a white plate.

Grilled Mediterranean Pork Tenderloin

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  • 1.33 lbs. lean pork tenderloin
  • 1 tbsp. olive oil
  • 2 garlic cloves, mined
  • 1/2 tsp. oregano
  • 1/2 tsp. thyme
  • 1/2 tsp. paprika
  • 1/2 tsp. garlic powder
  • 1/2 tsp. onion powder
  • 1/2 tsp. pepper
  • 1/4 tsp. salt

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Preheat the grill or a grill pan over medium high heat.


Mix together the oil, spices, and garlic. Rub over the pork.


Place the pork on the grill and cook for 7-8 minutes per side or until cooked to your liking. Let rest for 5 minutes before serving.


Oven method: Preheat the oven to 400 degrees. Bake 25-35 minutes until the pork is cooked to your liking. Let rest 5-10 minutes and slice into 1 inch pieces.

Nutritional Facts
Serving Size: 6 oz.
Amount Per Serving
Calories 201
Calories from Fat 60
% Daily Value *
Total Fat 7g
Saturated Fat 2g
Monounsaturated Fat 0g
Polyunsaturated Fat 0g
Cholesterol 98mg
Sodium 228mg
Total Carbohydrate 2g
Dietary Fiber 0g
Sugars 0g
Protein 32g

* Percent Daily Values are based on a 2,000 calorie diet. Your daily values may be higher or lower depending on your calorie needs.

The Nutritional Values provided are estimates only and may vary based on the preparation method.

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About the author Meet Kristen McCaffrey
Hi, I’m the cookbook author, recipe developer, and food enthusiast behind Slender Kitchen. I am obsessed with making healthy food that is easy to prepare and absolutely delicious. Meal planning is my secret weapon and I hope I can make meal time easier for you with our tried and tested recipes and foolproof meal plans. Learn More
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